The researchers isolated lung lymphocytes from the samples and used two-color flow cytometry to phenotypically characterize the cells. “We also now have a pathway that could be interrupted to prevent lung destruction in COPD.”įarrah Kheradmand and colleagues took lung samples from 28 ex-smokers who had been admitted to hospital for lung resection: 18 patients had moderate to severe COPD as well as evidence of emphysema, and ten patients had none. “We now know that T cells are not only present in chronic obstructive pulmonary disease, but are harmful,” comments Steven Shapiro from Brigham and Women's Hospital, Harvard Medical School, who was not involved in the study. T lymphocytes may have an important role in the pathogenesis of smoking-related emphysema, according to a new study by researchers from Houston, Texas, United States.
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